MLL gene deletion detection probe (MLL/CEP11)

MLL Gene Deletion Probe Detection Kit - 100µL/10 Tests

MLL gene rearrangements are associated with unfavorable outcome in infant acute lymphoblastic leukemia (ALL) and have intermediate prognosis in infant acute myeloid leukemia (AML). Application of fluorescence in-situ hybridization (FISH) allows detecting not only conventional MLL rearrangements, but also concurrent 3'-deletion of MLL gene. 

Myeloid/lymphoid leukemia (MLL) gene rearrangements are high risk cytogenetic characteristics of acute lymphoblastic leukemia (ALL). Translocations of this gene are well defined, and their impact on the patient’s prognosis is well known, but deletions of the same region are rare, and little is known about their prognostic significance and the significance of their accompanying translocations.

Product Introduction
This kit uses Orange fluorescein labeled MLL probe and Green fluorescein labeled CEP11, to combine MLL/CEP11 genes with the target site by in situ hybridization.

Product Main Components

The kit consists of MLL/CEP11 dual color probe

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).