KMT2A(MLL) gene break apart detection probe (MLL)

KMT2A(MLL) Gene Break Apart Probe  Detection Kit - 100µL/10 Tests

This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation.

This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.

Product Introduction

The kit uses orange fluorescein-labeled MLL probe and green fluorescein-labeled MLL probe to bind the MLL probe to the target detection site by in situ hybridization.

Product Main Components

The kit consists of MLL dual-color probes

Applicable Instruments
Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).