CCND1(BCL1) gene amplification detection probe (CCND1/CEP11)

CCND1(BCL1)/CEP11 Gene Amplification Probe Detection Kit - 100µL/10 Tests

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers.

Product Introduction
This kit uses Orange Fluorescein labeled CCND1 probe and Green Fluorescein labeled CEP11, to combine CCND1/CEP11 genes with the target site by in situ hybridization.

Product Main Components

The kit consists of CCND1/CEP11 dual color probe

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).