ETV6(TEL)/RUNX1(AML1) gene translocation detection probe (TEL/AML1)

ETV6(TEL)/RUNX1(AML1) Gene Translocation Probe Detection Kit - 100µL/10 Tests

RUNX1 is a transcription factor that forms a complex with the cofactor CBFB. This complex provides stability to the RUNX1 protein which is involved in the generation of hematopoietic stem cells and for their differentiation into myeloid and lymphoid lines. Loss of RUNX1 function has been shown to impair differentiation between myeloid and lymphoid lines often resulting in the development of leukemia.

ETV6 gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.

Product Introduction

The kit uses orange fluorescein-labeled ETV6 (TEL) probe and green fluorescein-labeled RUNX1 (AML1) probe to bind ETV6 (TEL)/RUNX1 (AML1) probe to the target detection site by in situ hybridization.

Product Main Components

The kit consists of ETV6 (TEL)/RUNX1 (AML1) dual color probe

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).