EWSR1 gene break apart detection probe (EWSR1)

 EWSR1 Gene Break Apart Probe Detection Kit - 100µL/10 Tests

EWSR1 (EWS RNA Binding Protein 1) gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis.

These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. [provided by RefSeq, Jul 2009].

Product Introduction
This kit uses Orange fluorescein and Green fluorescein to label EWSR1. EWSR1 probe can be bound to the target detection site by in situ hybridization.

Product Main Components

The kit consists of EWSR1 dual color probe

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).