MDM2 gene amplification detection probe (MDM2)

MDM2 Gene Amplification Probe Detection Kit - 100µL/10 Tests

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Product Introduction
This kit uses Orange fluorescein labeled MDM2 probe and Green fluorescein labeled CEP12, to combine MDM2/CEP12 genes with the target site by in situ hybridization.

Product Main Components

The kit consists of MDM2/CEP12 dual color probe

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).