E2A gene break apart detection probe (E2A)

E2A Gene Break Apart Probe Detection Kit - 100µL/10 Tests

Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression. TCF3 encodes for E2A protein, which belongs to the helix loop helix transcription factor family.

E2A activates transcription of downstream genes by binding to E-box motifs as a homo or hetero dimer. E2A plays an important role in B lymphocyte development. Therefore, deletion or mutations in TCF3 or even lowered activity of E2A are causes of B cell leukemia and lymphomas.

Product Introduction
This kit uses Orange fluorescein, Green fluorescein to label E2A probe and bind E2Agene with the target site by in situ hybridization.

Product Main Components

The kit consists of E2A dual color probe

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).