MDS chromosome and gene anomaly detection probe (D20S108/CEP8)

MDS (D20S108/CEP8) Chromosome and Gene Anomaly Probe Detection Kit - 100µL/10 Tests

Myelodysplastic syndrome (MDS) is a group of heterogeneous diseases that are generally considered to originate from hematopoietic stem cells and belong to malignant clonal diseases. Studies have shown that 40% to 60% of patients with MDS have non-randomized chromosomal anomalies, of which - the most common are 5/5q-, -7/7q-, +8, 20q-, and -Y. Among the common chromosomal anomalies in patients with MDS, some chromosomal anomalies have specific diagnostic value.

Immunosuppressive therapy is effective in some patients with simple +8, 20q-, or Y-; karyotype analysis also has important value in the classification, treatment, and prognosis of MDS, such as single Y-, 5q- or 20q- patients’ have a good prognosis, while patients with complex chromosomal anomalies (≥3 anomalies) or chromosome 7 anomalies have a poorer prognosis. Patients with other anomalies have a moderate prognosis. These anomalies are of great significance in the diagnosis, treatment, and prognosis of MDS.

Product Main Components

The kit consists of D20S108/CEP8 dual color probe

Product Introduction

The kit uses orange fluorescein-labeled D20S108 orange-red probe and green fluorescein-labeled CEP8 green probe to bind D20S108/CEP8 probe to the target detection site by in situ hybridization.

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).