1p/19q deletion detection probe (1p/19q)

1p/19q Gene Deletion Detection Probe Kit (Fluorescence In Situ Hybridization Method) - 200µL/10 Tests

Complete deletion of both the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q) (1p/19q co-deletion) is the molecular genetic signature of oligodendrogliomas, a subtype of primary brain tumors accounting for approximately ten to fifteen percent of all diffuse gliomas in adults 1,2.

The loss of one hybrid chromosome results in 1p and 19q loss of heterozygosity (LOH) 3. This molecular alteration is the result of an unbalanced whole-arm translocation between chromosomes 1 and 19 3 with the loss of the derivative t(1p;19q), which occurs early in the pathogenesis of oligodendrogliomas. Initially described in 1994 4, the biologic effect of 1p/19q co-deletion remains unclear. 1p/19q co-deletion is a valuable diagnostic, prognostic and predictive biomarker for the management of oligodendroglial tumors.

Product Main Components

The kit consists of 1p36/1q25 dual-color probe and 19q13/19p13 dual-color probe

Applicable Instruments
Fluorescence microscopy imaging system including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).