CDK4 (12q13)/SE12 detection probe (CDK4/CEP12)

CDK4(12q13)/CEP12 Probe Detection Kit - 100µL/10 Tests

CDK4 (Cyclin Dependent Kinase 4) encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers.  [provided by RefSeq, Jul 2008].

Product Introduction
This kit uses Orange fluorescein labeled CDK4 probe and Green fluorescein labeled CEP12, to combine CDK4/CEP12 genes with the target site by in situ hybridization.

Product Main Components

The kit consists of CDK4/CEP12 dual color probe

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).