USP6(17p13) gene break apart detection probe (USP6)

 TUSP6(17p13) Gene Break Apart Probe Detection Kit - 100µL/10 Tests

USP6 (Ubiquitin Specific Peptidase 6) belongs to a large subfamily of deubiquitinating enzymes involved in a variety of cellular processes, including intracellular trafficking, protein turnover, inflammatory signaling, and cell transformation. USP6 is located on chromosome 17p13 and is primarily expressed in testicular tissue. Interestingly,

USP6 is a hominoid-specific gene that was formed as result of a recent evolutionary fusion of the ancestor genes TBC1D3 (located on chromosome 17q12) to USP32 (located on chromosome 17q23). USP6 FISH is a useful test in cases where nodular fasciitis is a potential diagnostic consideration and in histological mimics.

Product Main Components

The kit consists of USP6 dual color probe

Intended use

The reagent carries out in situ hybridization staining on the basis of routine staining to provide doctors with auxiliary information for diagnosis. The test results are only for clinical reference and should not be used as the only basis for clinical diagnosis. Clinicians should comprehensively judge the test results in combination with the patient's condition, drug indications, treatment response and other laboratory test indicators.

Detection principle

Fluorescence in situ hybridization is a technique for directly observing specific nucleic acids in cells in vitro. According to the principle of base complementary pairing, the specific probe is complementary to the target sequence in the cell. Due to the fluorescence of the probe, the gene state of the hybrid probe and the target sequence can be clearly observed under the fluorescence microscope under the appropriate excitation light.

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).