DDIT3(12q13) gene break apart detection probe (DDIT3)

DDIT3(12q13) Gene Break Apart Probe Detection Kit - 100µL/10 Tests

DDIT3 (DNA Damage Inducible Transcript 3) gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis.

Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]. 

Product Introduction
This kit uses Orange fluorescein and Green fluorescein to label DDIT3. DDIT3 probe can be bound to the target detection site by in situ hybridization.

Product Main Components

The kit consists of DDIT3 dual color probe

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).