SRD(1p36) gene deletion detection probe (SRD/PBX1)

SRD(1p36) Gene Deletion Probe Detection Kit - 100µL/10 Tests

The 1p36 region is frequently deleted in a broad range of human cancers. The CHD5 gene acts as a tumour suppressor at 1p36 and is frequently deleted in human gliomas, leukaemia/lymphoma and neuroblastoma. This is the most common childhood extracranial solid tumour accounting for around 8%-10% of childhood cancers and 15% of childhood cancer deaths. The CHD5 gene has been characterised as the lead tumour suppressor candidate from the 1p36 SRD (smallest region of consistent deletion) region in neuroblastoma.

Product Main Components

The kit consists of SRD/PBX1 dual color probe

Intended use

The reagent carries out in situ hybridization staining on the basis of routine staining to provide doctors with auxiliary information for diagnosis. The test results are only for clinical reference and should not be used as the only basis for clinical diagnosis. Clinicians should comprehensively judge the test results in combination with the patient's condition, drug indications, treatment response and other laboratory test indicators.

Detection principle

Fluorescence in situ hybridization is a technique for directly observing specific nucleic acids in cells in vitro. According to the principle of base complementary pairing, the specific probe is complementary to the target sequence in the cell. Due to the fluorescence of the probe, the gene state of the hybrid probe and the target sequence can be clearly observed under the fluorescence microscope under the appropriate excitation light.

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).