ABL2(1q25) gene break apart detection probe (ABL2)

ABL2 Gene Break Apart Probe Detection Kit (Fluorescence In Situ Hybridization Method).  - 100µL/10 Tests

ABL2 (ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase) gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. [provided by RefSeq, Nov 2009].

Product Main Components

The kit consists of ABL2 dual color probe

Product Intended Use
This kit performs in situ hybridization staining on the basis of conventional staining to provide physicians with auxiliary information for diagnosis. The test results are for clinical reference only and should not be used as the only basis for clinical diagnosis. Clinicians should make comprehensive judgment on the test results based on factors such as the patient’s condition, drug indications, treatment response and other laboratory test indicators.

Detection Principle
Fluorescence in situ hybridization is a technique for directly observing specific nucleic acids in cells in vitro. According to the principle of complementary base pairing, a specific probe is complementary to the target sequence in the cell. Because the probe is fluorescent, the hybridization probe and the target sequence can be clearly observed under a fluorescence microscope under the appropriate excitation light and the genetic status is observed.

Applicable Instruments
Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).