TMPRSS2 gene break apart detection probe (TMPRSS2)

TMPRSS2 Break Apart Probe Detection Kit - 100µL/10 Tests

TMPRSS2 (Transmembrane Serine Protease 2) gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue.

The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). [provided by RefSeq, Apr 2020].

Product Introduction
This kit uses Orange fluorescein labeled TMPRSS2 probe and Green fluorescein labeled TMPRSS2, to combine TMPRSS2 gene with the target site by in situ hybridization.

Product Main Components

The kit consists of TMPRSS2 dual color probe

Applicable Instruments

Fluorescence microscopy imaging systems, including fluorescence microscopy and filter sets suitable for DAPI (367/452), Green (495/517), and Orange (547/565).