Biometra TGGE Maxi System (Discontinued)

This product has been discontinued.

For repair and maintenance please communicate with our service department at [email protected]

Biometra

High throughput for sensitive and cost effective mutation screening:

• Long separation distance for analysis of complex samples
• High parallel sample throughput
• High reproducibility thanks to Peltier powered temperature gradient
• Precast gels for mutation analysis

Precise

The heart of the Biometra® TGGE Maxi system is a temperature block powered by Peltier technology. Due to microprocessor control a strictly linear gradient can be generated providing maximum reproducibility. Thus assay conditions can be much better (and easier) controlled compared to conventional chemical gradients or temporal gradients using water baths.

Cost Saving

TGGE provides fast and cost effective mutation screening of PCR® fragments. Following pre-screening with TGGE only those samples are selected for direct sequencing that are different from the wildtype (standard). Thus the total number of sequenced samples can be dramatically reduced, saving time and money. Ready made gels for routine mutation screenings are available.

Sensitive

In contrast to direct sequencing TGGE can also detect mutations in mixed DNA samples. Whenever heterozygous DNA is to be analyzed, direct sequencing will not give a clear signal for the position of the mutation. This is especially problematic when the mutated material is masked by a high background of normal cells. TGGE reliably detects mutations in a 1:10 dilution (and higher) of wildtype DNA.