ADAMII-CDx Image-based immunophenotyping instrument
Catalog Number:
ADAMII-CDx
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In stock
ADAMII-CDx Image-Based Immunophenotyping Instrument
SKU: ADAMII-CDx
21 CFR PART 11 READY — GMP COMPLIANT
The ADAMII-CDx is a versatile 4-channel image-based immunophenotyping instrument engineered for cell therapy R&D and manufacturing process QC. Combining bright field imaging with three fluorescence channels, it performs absolute counting of CD marker positive cells using ready-to-use panel sets for T, NK, B, and monocyte subsets — delivering flow-cytometer-like accuracy without requiring specialized operators.
Key Highlights: 4-channel imaging (Bright field + 3 FL) • Absolute CD+ cell counting with ratio • Ready-to-use panels: T, NK, B, Monocyte • 10× objective with powerful LED optics • Auto-focusing • 21 CFR Part 11 compliance ready • High correlation to flow cytometry • Total cell counting, viability, cell size, growth curve • Apoptosis assay • 25 µL sample volume
Core Features
Cell Therapy Manufacturing QC
Designed to reduce labor-intensive and repetitive QC work across the entire cell therapy pipeline — from leukapheresis and isolation through purification, transfection, cell expansion, harvest, formulation, and final product QC.
Powerful 4-Channel Optics
10× objective lens with bright field and three independent fluorescence channels. Clearly observes immune cells, CAR-T cells, NK cells, B cells, PBMCs, stem cells, and even small-sized immune cells that challenge conventional brightfield systems.
Absolute CD Marker Counting
Every cell expresses specific surface proteins (CD markers). The ADAMII-CDx identifies cell populations and reports absolute counts plus subset ratios — essential for cell therapy development and release criteria.
Flow Cytometry Alternative
Non-specialist and unskilled users produce accurate, highly reproducible results comparable to flow cytometry. If your lab faces resource or training constraints with traditional FACS, the ADAMII-CDx is a practical, benchtop-sized alternative.
Ready-to-Use CD Marker Panels
| Panel | Fluorescence Channel 1 | Fluorescence Channel 2 | Fluorescence Channel 3 |
|---|---|---|---|
| T Cell Panel | CD4 (BV510) | CD8 (PE) | CD3 (PerCP) |
| NK Cell Panel | CD3 (BV510) | CD56 & CD16 (PE) | CD45 (PerCP) |
| B Cell Panel | CD3 (BV510) | CD19 (PE) | CD45 (PerCP) |
| Monocyte Panel | CD3 (BV510) | CD14 (PE) | CD45 (PerCP) |
Optical Configuration
| Channel | Dye | Light Source | Excitation Filter | Emission Filter |
|---|---|---|---|---|
| Bright Field | — | 530 LED (up-light) | — | 572 nm |
| Fluorescence 1 | BV510 | 405 LED | 390 nm | 525 nm |
| Fluorescence 2 | PE | 530 LED | 510 nm | 572 nm |
| Fluorescence 3 | PerCP | 530 LED | 525 nm | 635 nm |
Technical Specifications
| Specification | Details |
|---|---|
| SKU / Cat. No. | ADAMII-CDx |
| Objective Lens | 10× |
| Imaging Channels | Bright field + 3 fluorescence channels |
| Light Sources | 530 LED (BF up-light), 405 LED, 530 LED (FL) |
| Analysis Time | Approx. 4 min 20 sec (75 frames) |
| Loading Sample Volume | 25 µL (1ch, 2ch slides) |
| Measuring Volume | ≤ 7.8 µL |
| Measuring Range | 5 × 10⁴ – 5 × 10⁶ cells/mL |
| Focusing | Auto-focusing |
| 21 CFR Part 11 | Compliance ready |
| Dimensions (W × D × H) | 300 × 420 × 370 mm |
| Net Weight | 19.3 kg |
Applications
- Cell therapy R&D and manufacturing process QC
- Absolute counting of CD marker positive cells (T, NK, B, monocyte subsets)
- CAR-T cell identification and potency assessment
- Immune cell profiling in PBMC and stem cell preparations
- Total cell counting and viability via bright field and fluorescence
- Cell size distribution and growth curve monitoring
- Apoptosis assay for cell health and product stability
- Regulated environments requiring 21 CFR Part 11 documentation
For research use only. Not approved for diagnostic or therapeutic use. ADAMII-CDx counting slides, staining reagents, and panel kits sold separately. Specifications subject to change without notice.
| Analysis time | 4 min 20 sec (75 frames) |
|---|---|
| Loading sample volume | 25μL (1ch, 2ch |
| Measuring volume | ≤ 7.8 μL |
| Measuring range | 5 x 10E4 to 5 x 10E6 cells/mL |
| Focusing | Auto-focusing |
| Net Weight | 19.3 kg |
| Dimensions | 300 mm (W) x 420 mm (D) x 370 mm (H) |
| Objective Lens | 10X |
| Light Source | Bright field, UV, Blue, Green LED |
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