Microarray Scanner - MBI Innoscan AutoLoader 1100AL
The MBI Innoscan AutoLoader 1100AL combines ultra-high resolution and high-level automation for fast, whole-slide imaging. With three excitation wavelengths and a 24-slide autoloader, it is the ideal platform for cell microarrays, tissue immunofluorescence, and classic three-color microarray analysis.
Characterized by its ease of use, performance, and versatility, the InnoScan 1100 AL delivers the highest resolution on the market — up to 0.5µm/pixel (20× objective equivalent) — with real-time autofocus and confocal PMT detection for publication-quality images.
Ultra-High Resolution
0.5µm/pixel — highest resolution microarray scanner on the market. 20× objective equivalent.
Full Automation
24-slide autoloader with barcode reader. Fully unattended high-throughput scanning.
3-Color Confocal
Simultaneous detection via 3 high-performance analog PMTs with >10⁶ dynamic range (XDR).
Technology
The InnoScan 1100 is a confocal scanner equipped with 3 excitation lasers (488, 532, and 635 nm) coupled with 3 extremely sensitive photomultiplier tubes (PMT) for whole-slide image acquisition. The PMTs are linear over the entire dynamic range (1% to 100%), making it easy to set gain for perfect fluorescence signal adjustment and saturation avoidance.
A real-time autofocus system adapts to substrate distortion, ensuring the entire reading area is completely uniform. The Extended Dynamic Range mode (XDR) delivers a dynamic range of over 10⁶, capable of detecting the weakest signals while avoiding saturated spots.
- Real-time autofocus or in-content focus system
- 7-position filter wheel (1 standard fluorescence + 1 neutral density filter per channel; 5 additional filters on request)
- Manual focus offset: 300 µm range, 1 µm increment
- Automatic barcode reading for traceability
- Ethernet interface
Applications
The InnoScan 1100 AL is the ideal tool for fast and automated whole-slide imaging across multiple research fields:
Compatible Fluorophores
| Laser Wavelength | Compatible Fluorophores |
|---|---|
| 488 nm | Cy2, FITC, Alexa Fluor 458, Alexa Fluor 488 |
| 532 nm | Cy3, Alexa Fluor 544, Alexa Fluor 555 |
| 635 nm | Cy5, DRAQ5, Alexa Fluor 647 |
* Laser power is adjustable with 2 power levels available per channel.
Technical Specifications
Optical & Detection
| Pixel Size | 0.5 – 40 µm/pixel |
| Excitation Wavelengths | 488 nm, 532 nm, 635 nm |
| Laser Type | Laser diode, adjustable (2 power levels) |
| Detection | Real-time confocal with 3 analog PMTs |
| PMT Gain | 0 – 100% (linear 1 – 100%) |
| Optical Filter | 7-position filter wheel |
| Dynamic Range | > 10⁴ (normal) / > 10⁶ (XDR mode) |
| Uniformity | > 95% |
Scanning Performance
| Scanning Speed | 10 – 35 lines/sec |
| Scan Time (10 µm, 3-color) | ~3.5 min per whole slide |
| Scan Time (1 µm, 22×22 mm²) | ~10.5 min |
| Scanning Area | Up to 22 × 74 mm² |
| Focus | Real-time autofocus + manual offset |
Sample & Loader
| Slide Size | Standard microscope slides: 25–26 × 75–76 mm² (1" × 3") |
| Slide Thickness | 0.9 – 1.2 mm |
| Loader Capacity | 24 slides (AutoLoader) |
| Barcode Reader | Automatic |
System & Software
| Image Format | TIFF (16-bit / 20-bit in XDR mode) |
| Interface | Ethernet |
| Acquisition Software | MAPIX (image acquisition & spot quantification) |
| Autoloader Software | Fully integrated in MAPIX |
| Power Supply | 100–240 VAC, 1.2 A, 50–60 Hz |
Physical
| Dimensions (L×D×H) | 322 × 656 × 439 mm (12.7" × 25.8" × 17.3") |
| Weight | 35 kg (77.1 lbs) |
MAPIX Software
Every InnoScan 1100 AL includes MAPIX — the integrated image acquisition and spot quantification software. MAPIX controls the full scanning workflow, from automated slide loading and barcode tracking to image capture, spot detection, and quantitative analysis. The autoloader module is fully embedded, enabling unattended batch processing of up to 24 slides with complete traceability.
Standard Package
- InnoScan 1100 AL confocal fluorescence scanner with 24-slide autoloader
- 3 excitation lasers (488, 532, 635 nm) with 3 analog PMT detectors
- 7-position filter wheel with standard fluorescence and neutral density filters
- Real-time autofocus system
- Automatic barcode reader
- MAPIX image acquisition & quantification software (with autoloader module)
- Validation slide for performance verification
- Computer system
| Resolution | from 0.5 to 40 µm/pixel |
|---|---|
| Excitation wavelength | 488nm, 532nm and 635nm |
| Scanning speed | 20 to 35 lines/sec. (25 lines/sec. max for 0.5µm pixel size) 3.5 minutes to scan a whole slide at a 10 µm/pixel and 3 colors 10.5 min. for an area of 22 x 22 mm2 at 1 µm/pixel and 3 colors |
| Scanning area | 22 x 74 mm^2 |
| Dynamic range (linearity) | 10^6 |
| Laser | Laser diode, adjustable (2 laser power available) |
| Gain PMT | Linear from 0 to 100 % (step 0.1 from 0.1 to 1% and 1 from 1 to 100%) |
| Autofocus | Automatic or manual |
| Detection | Analog PMT confocal detection |
| Chip Format | Standard microscope slides norm ISO 8037-1 25 x 77 mm2 (1" x 3’’) |
| Interface | ethernet |
| Image format | 16-bit and 20-bit TIFF |
| Sample | All standard microscope slide 25 x 75mm^2 / 1 x 3 " |
| Barcode reader | Yes |
| Dimensions | 33 x 66 x 44 cm (13” x 26” x 17.3”) |
| Net Weight | 35 Kg (77.16lbs) |
| Option: Autoloader software | Total integration in the MAPIX software coming with the Innoscan Scanners |
